Characterization of the anti-α-Gal antibody profile in association with Guillain-Barré syndrome, implications for tick-related allergic reactions

Humans evolved by losing the capacity to synthesize glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in develop a protective response mediated anti-α-Gal IgM/IgG antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can alpha-Gal syndrome (AGS), recently diagnosed disease mainly associated with allergic reactions mammalian meat consumption. The etiology of AGS is exposure tick bites and IgE antibody α-Gal-containing glycoproteins glycolipids. objective study was characterize association immune-mediated peripheral neuropathy, Guillain-Barré (GBS), compare it different factors known modulate α-Gal such as development bites. results showed significant decrease GBS patients when compared healthy individuals. In contrast, levels did not change affected patients, but expected, significantly increased individuals exposed tick-associated allergies. These suggest that immune pathways production are independent. Further studies should consider susceptibility patients.